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Effects of a traditional fermented grape‐based drink ‘hardaliye’ on antioxidant status of healthy adults: a randomized controlled clinical trial
Author(s) -
Amoutzopoulos Birdem,
Löker Gül B,
Samur Gülhan,
Çevikkalp Senem A,
Yaman Mustafa,
Köse Timur,
Pelvan Ebru
Publication year - 2013
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6158
Subject(s) - homocysteine , malondialdehyde , antioxidant , vitamin c , randomized controlled trial , antioxidant capacity , medicine , food science , chemistry , biochemistry
BACKGROUND The antioxidative effects of the traditional grape‐based beverage, hardaliye, were investigated with a 40‐day randomized controlled clinical trial on 89 healthy adults. Subjects were randomly divided into three groups: high hardaliye ( HH ), low hardaliye ( LH ) and control group. HH and LH groups consumed 500 mL and 250 mL hardaliye per day, respectively, and the control group did not consume any hardaliye. Dien conjugate ( DC ), malondialdehyde ( MDA ), vitamin C, total antioxidant capacity ( TAC ) and homocysteine concentrations were measured in fasting blood samples collected at baseline and after intervention . RESULTS Significant decreases in DC , MDA and homocysteine concentrations were observed in HH and LH groups ( P < 0.001) after intervention, whereas the control group showed no change. The reduction in homocysteine was significantly different between HH and LH groups ( P < 0.001), except for DC and MDA . TAC and vitamin C were slightly increased; however, the change was not statistically significant . CONCLUSION Dietary supplementation with hardaliye affect the MDA , DC and homocysteine levels in blood, possibly due to the presence of antioxidant compounds. Dose response was only observed for homocysteine. Further studies need to be performed to assess the effects on antioxidant capacity. © 2013 Society of Chemical Industry