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Role of Adhatoda vasica (L.) Nees leaf extract in the prevention of aflatoxin‐induced toxicity in Wistar rats
Author(s) -
Brinda Rajendran,
Vijayanandraj Selvaraj,
Uma Doraiswamy,
Malathi Dorairaj,
Paranidharan Vaikuntavasan,
Velazhahan Rethinasamy
Publication year - 2013
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6093
Subject(s) - aflatoxin , catalase , alkaline phosphatase , toxicity , superoxide dismutase , alanine aminotransferase , biology , pharmacology , chemistry , food science , traditional medicine , toxicology , antioxidant , biochemistry , enzyme , medicine , endocrinology , organic chemistry
Background Aflatoxin contamination of various foodstuffs and agricultural commodities is a major problem worldwide. Several strategies have been reported for the detoxification of aflatoxins in contaminated foods and feeds, but all these methods have their own shortcomings. Traditional medicinal plants are potential sources of aflatoxin‐detoxifying compounds. In this study a spray‐dried formulation of Adhatoda vasica (L.) Nees leaf extract was prepared and its chemopreventive effect on aflatoxin B1 ( AFB1 )‐induced biochemical changes in the liver and serum of Wistar rats was investigated . Results Administration of AFB1 (1.5 mg kg −1 body weight ( BW ) intraperitoneally) to rats significantly reduced the activities of superoxide dismutase and catalase in liver tissues and increased the activities of aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase and the levels of very‐low‐density lipoprotein, low‐density lipoprotein and cholesterol in blood serum. However, pre‐feeding of rats with A. vasica formulation (500 mg kg −1 BW for 7 days) protected the animals from AFB1 ‐induced biochemical changes during subsequent exposure to AFB1 . Conclusion Pre‐feeding of rats with A. vasica formulation counteracted the hepatic dysfunction induced by subsequent treatment with AFB1 . This formulated A. vasica extract offers a biologically safe alternative to detoxify aflatoxin and has huge potential to be used in the poultry industry to reduce aflatoxicosis. © 2013 Society of Chemical Industry