Premium
Hypolipidaemic effects of cyanidin 3‐glucoside rich extract from black rice through regulating hepatic lipogenic enzyme activities
Author(s) -
Um Min Young,
Ahn Jiyun,
Ha Tae Youl
Publication year - 2013
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.6070
Subject(s) - chemistry , food science , malic enzyme , cholesterol , triglyceride , enzyme , medicine , dehydrogenase , endocrinology , biochemistry , biology
BACKGROUND Black rice is rich in anthocyanins, especially cyanidin‐3‐glucoside ( C3G ). This study examined the effects of a C3G ‐rich extract from black rice on hyperlipidaemia induced by a high fat/cholesterol diet ( HFCD ) in rats.RESULTS Male Sprague–Dawley rats were fed either HFCD or HFCD containing 150 mg kg −1 body weight C3G ( HFCD + C3G ) for 4 weeks. We found that C3G significantly decreased serum levels of total cholesterol, free cholesterol, triglycerides, and free fatty acids in rats fed a HFCD . Similarly, hepatic cholesterol and triglyceride levels and the activities of hepatic lipogenic enzymes (malic enzyme and glucose‐6‐phosphate dehydrogenase) were significantly reduced by C3G supplementation.CONCLUSION These results suggest that C3G can ameliorate HFCD ‐induced hyperlipidaemia in part by modulating the activities of hepatic lipogenic enzymes. © 2013 Society of Chemical Industry