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Amaranthus viridis Linn., a common spinach, modulates C‐reactive protein, protein profile, ceruloplasmin and glycoprotein in experimental induced myocardial infarcted rats
Author(s) -
Saravanan Ganapathy,
Ponmurugan Ponnusamy
Publication year - 2012
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.5652
Subject(s) - ceruloplasmin , myocardial infarction , albumin , medicine , globulin , glycoprotein , endocrinology , chemistry , reactive oxygen species , spinach , biochemistry
BACKGROUND: Glycoprotein is one of the components of the cardiac extracellular matrix and plays an important role in cardiac remodelling during various cardiac diseases, including myocardial infarction (MI). This study was aimed at evaluating the preventive role of Amaranthus viridis Linn. on C‐reactive protein (CRP), total protein, albumin, globulin, ceruloplasmin and glycoproteins in the serum and heart of experimental induced myocardial infarcted (MI) rats. RESULTS: MI was induced in male Wistar rats by subcutaneous injection of 20 mg kg −1 isoproterenol (ISO) kg −1 body weight (BW) twice at an interval of 24 h. ISO‐induced MI rats showed a significant increase in the levels of serum CRP and ceruloplasmin and a significant decrease in the levels of serum total protein, albumin and globulin. Glycoprotein levels in the serum and heart were increased in ISO‐induced MI rats. Oral administration of 300 mg A. viridis kg −1 BW day −1 for a period of 45 days altered the metabolic derangement in ISO‐induced MI rats. CONCLUSION: This study exemplifies the protective effect of A. viridis on ISO‐induced cardiotoxicity in male Wistar rats. The data further reinforce the cardioprotective effect of A. viridis by altering CRP and glycoprotein levels. Copyright © 2012 Society of Chemical Industry