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Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double‐blind, placebo‐controlled study
Author(s) -
Kanzaki Noriyuki,
Saito Kayo,
Maeda Akifumi,
Kitagawa Yoshinori,
Kiso Yoshinobu,
Watanabe Keita,
Tomonaga Akihito,
Nagaoka Isao,
Yamaguchi Hideyo
Publication year - 2011
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.4660
Subject(s) - osteoarthritis , chondroitin sulfate , placebo , medicine , glucosamine , dietary supplement , randomized controlled trial , gastroenterology , food science , biochemistry , biology , pathology , glycosaminoglycan , alternative medicine , anatomy
BACKGROUND: Oral glucosamine and chondroitin sulfate, alone and in combination, have been used worldwide for the treatment of osteoarthritis (OA), but their efficacy is controversial. This clinical study was aimed at investigating the potential of a dietary supplement containing glucosamine and chondroitin sulfate in combination with derivatives of quercetin, a naturally occurring flavonoid, (GCQ supplement) for knee OA care. RESULTS: A randomized, double‐blind, placebo‐controlled study was conducted in 40 Japanese subjects with symptomatic knee OA. Subjects were randomly assigned to GCQ supplement (1200 mg glucosamine hydrochloride, 60 mg chondroitin sulfate and 45 mg quercetin glycosides per day) or placebo and the treatment and follow‐up were continued for 16 weeks. The results of symptomatic efficacy assessment based on Japanese Orthopaedic Association criteria showed that scores for two of the four symptom/function subscales, as well as the aggregate scores, were significantly improved at week 16 or earlier in the GCQ group compared to the placebo group. Moreover, analyses of cartilage metabolism biomarkers showed a trend of improvement in type II collagen synthesis/degradation balance in the GCQ group during follow‐up. CONCLUSION: GCQ supplement was thought to be more effective than placebo in decreasing the intensity of knee OA‐associated clinical symptoms. Copyright © 2011 Society of Chemical Industry