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Effects of albusin B (a bacteriocin) of Ruminococcus albus 7 expressed by yeast on growth performance and intestinal absorption of broiler chickens—its potential role as an alternative to feed antibiotics
Author(s) -
Wang HanTsung,
Yu Chi,
Hsieh YaHui,
Chen ShiauWei,
Chen BaoJi,
Chen ChingYi
Publication year - 2011
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.4463
Subject(s) - broiler , biology , antibiotics , lactobacillus , jejunum , feed additive , zoology , ruminococcus , feed conversion ratio , intestinal villus , food science , bacteriocin , virginiamycin , microbiology and biotechnology , body weight , veterinary medicine , antimicrobial , feces , fermentation , small intestine , biochemistry , endocrinology , medicine
BACKGROUND: Bacteriocins with antimicrobial activity are considered as potential alternatives to antibiotics. The aim of this study was to investigate the effect of albusin B (bacteriocin) of Ruminococcus albus 7 expressed by yeast on the growth performance of broiler chickens. Ninety 1‐day‐old healthy broiler chickens were randomly divided into three groups: control, albusin B (2.5 g kg −1 ) and nosiheptide (2.5 mg kg −1 , antibiotic control). Growth performance and intestinal functions were measured at 5 weeks of age. RESULTS: Albusin B‐supplemented broilers showed increased body weight gain compared with control broilers (54.7 ± 5.3 vs 48.5 ± 6.1 g day −1 per bird, P < 0.05). Broilers supplemented with nosiheptide had a less developed mucosal layer than broilers in the other two groups. Compared with the control group, broilers supplemented with albusin B or nosiheptide showed increased mRNA expression of sGLT1, GLUT2 and PEPT1 in the jejunum ( P < 0.05). The faecal Lactobacillus count was higher in the albusin B group than in the other two groups ( P < 0.05). CONCLUSION: Albusin B supplementation increased intestinal absorption and elevated the faecal Lactobacillus count, thereby promoting the growth performance of broiler chickens. These improvements resulting from albusin B supplementation provide evidence of potential alternatives to antibiotics in broiler chicken feed. Copyright © 2011 Society of Chemical Industry