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Influence of dietary supplementation with Bacillus ‐fermented adlay on lipid metabolism, antioxidant status and intestinal microflora in hamsters
Author(s) -
Wang ChungYi,
Lin HsinTang,
Wu SheChing
Publication year - 2011
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.4450
Subject(s) - antioxidant , fermentation , food science , triglyceride , thiobarbituric acid , lipid metabolism , cholesterol , lactic acid , bacillus (shape) , tbars , chemistry , biology , bacteria , lipid peroxidation , biochemistry , microbiology and biotechnology , genetics
BACKGROUND: The effects of polished and dehulled Bacillus ‐fermented adlay on lipid metabolism, antioxidant status and intestinal microflora were examined in hyperlipidaemic hamsters fed a high‐cholesterol diet. RESULTS: Hamsters administered Bacillus ‐fermented adlay experienced significantly reduced ( P < 0.05) serum and hepatic total cholesterol (by 37–43% and 42–49% respectively) and triglyceride (by 22–27% and 30–35% respectively) levels compared with the high‐cholesterol group. Lower low‐density lipoprotein cholesterol/high‐density lipoprotein cholesterol ratios in serum and increased cholesterol (by 47–52%) and triglyceride (by 40–47%) contents in faeces were also observed. Bacillus ‐fermented adlay lowered the levels of thiobarbituric acid‐reactive substances, thus increasing total antioxidant and superoxide dismutase activities. In particular, polished Bacillus ‐fermented adlay had satisfactory antioxidant activity, similar to that of commercially available natto. Moreover, hamsters fed Bacillus ‐fermented adlay harboured greater populations of lactic acid bacteria, few coliforms and little Clostridium perfringens . CONCLUSION: This study has shown that changes in lipid metabolism, antioxidant status and intestinal microflora can be greatly modulated by Bacillus ‐fermented adlay, suggesting potential novel approaches to the treatment of primary cardiovascular and intestinal diseases. Copyright © 2011 Society of Chemical Industry