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Protective effect of a marine oligopeptide preparation from Chum Salmon ( Oncorhynchus keta ) on radiation‐induced immune suppression in mice
Author(s) -
Yang Ruiyue,
Pei Xinrong,
Wang Junbo,
Zhang Zhaofeng,
Zhao Haifeng,
Li Qiong,
Zhao Ming,
Li Yong
Publication year - 2010
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.4077
Subject(s) - immune system , splenocyte , spleen , biology , cytokine , adjuvant , apoptosis , andrology , lymphocyte , radiosensitivity , stimulation , immunology , chemistry , endocrinology , medicine , radiation therapy , biochemistry
BACKGROUND: A marine oligopeptide preparation (MOP) obtained from Chum Salmon ( Oncorhynchus keta ) by the method of enzymatic hydrolysis, has been found to enhance the innate and adaptive immunities through stimulation of the secretion of cytokines in mice. The current study aimed to further investigate the protective effect of MOP on radiation‐induced immune suppression in mice. RESULTS: Female ICR mice (6–8 weeks old) were randomly divided into three groups, i.e. blank control, irradiation control and MOP (1.350 g kg −1 body weight) plus irradiation‐treated group. MOP significantly increased the survival rate and prolonged the survival times for 30 days after irradiation, and lessened the radiation‐induced suppression of T‐ or B‐lymphocyte proliferation, resulting in the recovery of cell‐mediated and humoral immune functions. This effect may be produced by augmentation of the relative numbers of radioresistant CD 4 + T cells, enhancement of the level of immunostimulatory cytokine, IL‐12, reduction of the level of total cellular NF‐κB through the induction of IκB in spleen and inhibition of the apoptosis of splenocytes. CONCLUSION: We propose that MOP be used as an ideal adjuvant therapy to alleviate radiation‐induced injuries in cancer patients. Copyright © 2010 Society of Chemical Industry