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Opioid activity of Humana formula for newborns
Author(s) -
Jarmołowska Beata,
SzłapkaSienkiewicz Edyta,
Kostyra Elżbieta,
Kostyra Henryk,
Mierzejewska Dagmara,
MarcinkiewiczDarmochwał Katarzyna
Publication year - 2007
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2951
Subject(s) - hydrolysate , opioid peptide , pepsin , opioid , trypsin , naltrexone , peptide , chemistry , pharmacology , biochemistry , biology , enzyme , hydrolysis , receptor
Recent investigations have suggested that novel food should be evaluated not only from the nutritional but also from the physiological point of view. Opioid peptides derived from milk belong to compounds whose physiological importance has not yet been fully recognized. The commercial Humana formula for newborns sold on the Polish market was assayed in the study. Four opioid peptides with agonistic and antagonistic activity were found in a peptide extract from the Humana formula and its pepsin–trypsin hydrolysate: β‐casomorphin‐5, casoxin C and 6 and lactoferroxin A. The opioid activity of the peptide extracts was determined by examining their influence on the motor activity of isolated rabbit intestine. In conclusion, it was suggested that the opioid activity of the formulas could be an additional indicator of their diversity. Copyright © 2007 Society of Chemical Industry