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Absence of a hypocholesterolaemic action of chitosan in high‐serum‐cholesterol rabbits
Author(s) -
Hirano Shigehiro,
Akiyama Yasutoshi
Publication year - 1995
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740690114
Subject(s) - cholesterol , chitosan , action (physics) , food science , chemistry , biochemistry , quantum mechanics , physics
In rabbits fed a 0.9% cholesterol‐enriched (to 9 g kg −1 ) and 20 g kg −1 chitosan‐supplemented diet, total faecal bile acid and sterol levels increased 1.2‐1.4 times (cholic acid 5.0 times, and cholesterol 1.5 times) those in rabbits fed a cholesterol‐enriched (to 9g kg −1 ) diet. The serum cholesterol and triacylgiycerol levels of high‐serum‐cholesterol rabbits were affected neither by feeding with a 20 g kg −1 chitosan‐supplemented diet nor by intravenous injection with chitosan of low molecular weight (c3000) or chitosan oligosaccharides (300‐1162) daily. These data indicate that chitosan plays a hypocholesterolaemic action only in the intestine.