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Chromium in the gastrointestinal tract of the rat
Author(s) -
Chen Ying,
StoddardGilbert Kay,
Blincoe Clifton
Publication year - 1989
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740470105
Subject(s) - chromium , gastrointestinal tract , chromate conversion coating , chemistry , small intestine , solubility , digestive tract , size exclusion chromatography , chromatography , biochemistry , medicine , enzyme , organic chemistry
Chromium from feed intrinsically labelled with 51 Cr was either fed to laboratory rats or mixed in vitro with gastrointestinal tract contents. The solubility, protein association and molecular size were measured. Chromium from intrinsically labelled feed did not appear as inorganic chromium in the gastrointestinal tract of the rat. One‐fourth to one‐half of the chromium in the small intestine remained in solution after centrifugation for 10 min at 12000 × g. The chromium in solution had the same exclusion volume on gel filtration chromatography throughout the gastrointestinal tract. Any protein association was quite labile. With high‐fibre feed, more chromium was not soluble and probably was not available for absorption. Chromate administered with feed formed complexes with the feed and behaved similarly to intrinsically labelled feed. Chromate fed to fasted rats associated with large, possibly protein‐containing, sedimentable particles in the gastrointestinal tract of the rat.