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Simultaneous determination of 2,4,6‐trichloroanisole, 2,3,4,6‐tetrachloroanisole and pentachloroanisole in foods and packaging materials by high‐resolution gas chromatography‐multiple ion monitoring‐mass spectrometry
Author(s) -
Whitfield Frank B.,
Shaw Kevin J.,
Nguyen T. H. Ly
Publication year - 1986
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740370112
Subject(s) - chromatography , mass spectrometry , detection limit , extraction (chemistry) , gas chromatography , gas chromatography–mass spectrometry , calibration curve , selected ion monitoring , chemistry , reproducibility , resolution (logic) , analytical chemistry (journal) , artificial intelligence , computer science
A method has been developed for the determination of 2,4,6‐trichloroanisole, 2,3,4,6‐tetrachloroanisole and pentachloroanisole in foods and packaging materials. Using combined high‐resolution gas chromatography‐multiple ion monitoring‐mass spectrometry, and with the addition of 3,5‐dimethyl‐2,4,6‐trichloroanisole as an internal standard, a series of calibration curves were prepared covering the concentration range 0.1 to 100 μg kg −1 . The detection limit, with quantitation by extrapolation only, was 0.01 μg kg −1 . The mean extraction efficiency of the combined distillation‐extraction step was greater than 90% for each of the chloroanisoles analysed. The mean extraction efficiency for the internal standard was 105%. The reproducibility of the results obtained in the gas chromatography‐mass spectrometry step was assessed and the coefficients of variation lay in the range from 2 to 11%.