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Distribution of diethylstilboestrol in pigs
Author(s) -
Bates Michael L.,
Warwick Michael J.,
Shearer George,
Harwood David J.,
Herriman Ira D.,
Heitzman Raymond J.,
Watson David H.
Publication year - 1985
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740360106
Subject(s) - radioimmunoassay , urine , metabolite , feces , kidney , distribution (mathematics) , metabolism , biology , endocrinology , medicine , zoology , paleontology , mathematics , mathematical analysis
The synthetic growth promoter diethylstilboestrol (DES) administered orally to pigs can be detected by radioimmunoassay (RIA) analysis of kidney, liver, faeces, bile and urine from animals fed continuously to slaughter, but not in muscle, fat or plasma. If treated animals are fed on material not containing DES for 72 h prior to slaughter, then the levels of parent compound and metabolite in all products decrease to become not significantly greater than those in control animals. The gross metabolism of DES in pigs and bovines appears to be similar.