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Insulin secretion in relation to fatness in cattle
Author(s) -
Gregory Neville G.,
Truscott Terry G.,
Wood Jeffrey D.
Publication year - 1982
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740330313
Subject(s) - tolbutamide , insulin , endocrinology , medicine , insulin response , biology , plasma glucose
The insulin secretory response to tolbutamide was examined in cattle to determine: whether this agent is insulinogenic in this species, what effect age has on insulin secreting ability, and whether the insulin response is related to body fatness. Intravenous injection of sodium tolbutamide (27 mg kg −0.75 ) caused a three‐ to sevenfold rise in plasma insulin concentration, but the response was delayed and protracted in comparison with that seen in non‐ruminants. The insulin response was higher at 20 than at 12 months of age. The insulin response was not related to the proportion of dissectible fat in the empty body, and it was lower in Hereford than Friesian steers despite the Herefords being slightly fatter. It was concluded that tolbutamide is insulinogenic in cattle and its effectiveness increases with age. Unlike the non‐ruminant, there is no association between fatness and insulin response to tolbutamide in cattle compared at the same age.