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Involvement of copper in microsomal mixed‐function oxidase reactions: A review
Author(s) -
Wahle Klaus W. J.,
Davies Neill T.
Publication year - 1977
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740280115
Subject(s) - mixed function oxidase , copper , chemistry , oxidase test , electron transport chain , hydroxylation , microsome , biochemistry , enzyme , organic chemistry
Microsomes from various mammalian tissues contain the components of a short, non‐phosphorylating electron transport chain which is an obligatory requirement for numerous mixed function oxidase reactions. Certain of these reactions, in particular Δ9‐desaturation of fatty acids and the hydroxylation of drugs, are influenced by dietary copper deficiency. The inhibition of Δ9‐desaturase activity by copper chelating agents and the reactivation by copper ions suggest that copper may be involved catalytically in the reaction. Copper also influences Δ6‐desaturation of fatty acids, and the synthesis of prostaglandins. Copper‐proteins are ideally suited as terminal components of electron transport chains and as such may function in a greater variety of mixed‐function oxidase reactions than has hitherto been considered.