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Tissue concentrations of chloramphenicol after intramuscular injection in pigs
Author(s) -
Fabiansson Stefan,
Nilsson Torsten,
Bäckström Jörgen
Publication year - 1976
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740271212
Subject(s) - chloramphenicol , intramuscular injection , muscle tissue , chemistry , body weight , withdrawal time , gas chromatography , chromatography , antibiotics , biology , medicine , endocrinology , biochemistry , colorectal cancer , colonoscopy , cancer
Tissue concentrations of chloramphenicol in pigs have been studied at 3, 6, 18, 72, and 168 h after intramuscular administration of chloramphenicol at a dosage of 20 mg/kg body weight. The determination of chloramphenicol concentrations has been performed by a biological method as well as by gas chromatography. The biological method proved to be insufficient for the demonstration of tissue residues of chloramphenicol after intramuscular administration in pigs at current dosage. Using gas chromatography a maximum mean concentration of approx. 3 μg/g was demonstrated in the muscle tissues at 3 and 6 h postinjection. Three and 6 days after the injection of chloramphenicol, the tissue concentration was slightly lower than 0.05 μg/g. A minimum period of 3 days withdrawal between injection of chloramphenicol in pigs and slaughter is recommended.