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Chance of glutamic acid runs in gliadins and caseins
Author(s) -
Ewart J. A. D.
Publication year - 1973
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740240912
Subject(s) - gliadin , glutamine , glutamic acid , amino acid , sequence (biology) , coeliac disease , casein , chemistry , biochemistry , gluten , medicine , disease
Probability calculations based on amino acid compositions show that (Glx) 5 and more than one (Glx) 4 will almost certainly occur in wheat gliadin, provided that the amino acid sequences conform approximately to a random pattern. (Gln) 6 is probable. (Glx) 3 is likely to be the longest run in caseins. No major departures from a random arrangement were observed in calculations on ten standard proteins of known sequence. The possibility is raised that specificity of gliadin in coeliac disease may be linked with runs of glutamine. Tables of probabilities could be of use in sequential analysis.