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Tissue and milk residues arising from the ingestion of single doses of diquat and paraquat by cattle
Author(s) -
Stevens M. A.,
Walley J. K.
Publication year - 1966
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740171008
Subject(s) - diquat , paraquat , ingestion , chemistry , urine , excretion , feces , metabolism , zoology , food science , biochemistry , biology , paleontology
The fate of 14 C‐diquat and 14 C‐paraquat administered orally in single doses to cattle has been studied. In lactating cows, very little (<0.02%) of administered radioactivity appears in the milk, and then largely as metabolic products. Milk obtained in these trials contained levels of paraquat or diquat which in all cases were so low that it could safely be consumed by humans. Only small amounts (< 5%) of the administered radioactivity appears in the urine and in this case also largely as breakdown products. The bulk of the radioactivity appears in the faeces. In a calf slaughtered one day after dosage with 14 C‐diquat very little (< 0.01 ppm ion) diquat or its metabolites were found in the muscle tissue. The organs involved in metabolism and excretion, the kidneys and liver, contained relatively small amounts (equivalent to 0·7 ppm and 0·2 ppm ion, respectively) of diquat and its metabolites.