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N ‐acylation of N ‐methylcarbamate insecticides and its effect on biological activity
Author(s) -
Fraser J.,
Clinch P. G.,
Reay R. C.
Publication year - 1965
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740161008
Subject(s) - cholinesterase , acylation , toxicity , chemistry , in vitro , toxicology , biological activity , biology , pharmacology , biochemistry , organic chemistry , catalysis
N ‐Acylated N ‐methylcarbamates have been prepared and tested for contact/stomach poison and systemic insecticidal activities, mammalian toxicity and in vitro anticholinesterase activity. The N ‐acyl derivatives in general have lower mammalian toxicities and somewhat lower insecticidal activities than the corresponding unacylated N ‐methylcarbamates and are relatively poor inhibitors of bee cholinesterase. Tentative reasons are given for these effects.