N ‐acylation of  N ‐methylcarbamate insecticides and its effect on biological activity | Zendy

Fraser J. | Zendy; Clinch P. G. | Zendy; Reay R. C. | Zendy

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N ‐acylation of N ‐methylcarbamate insecticides and its effect on biological activity

Author(s) -

Fraser J.,

Clinch P. G.,

Reay R. C.

Publication year - 1965

Publication title -

journal of the science of food and agriculture

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 142

eISSN - 1097-0010

pISSN - 0022-5142

DOI - 10.1002/jsfa.2740161008

Subject(s) - cholinesterase , acylation , toxicity , chemistry , in vitro , toxicology , biological activity , biology , pharmacology , biochemistry , organic chemistry , catalysis

N ‐Acylated N ‐methylcarbamates have been prepared and tested for contact/stomach poison and systemic insecticidal activities, mammalian toxicity and in vitro anticholinesterase activity. The N ‐acyl derivatives in general have lower mammalian toxicities and somewhat lower insecticidal activities than the corresponding unacylated N ‐methylcarbamates and are relatively poor inhibitors of bee cholinesterase. Tentative reasons are given for these effects.

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