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Synergistic effects of some compounds related to 2‐diethylaminoethyl 2,2‐diphenyl‐n‐pentanoate (SKF 525A) on the insecticidal activity of pyrethrins
Author(s) -
Bates A. N.,
Hewlett P. S.,
Lloyd C. J.
Publication year - 1965
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740160601
Subject(s) - piperonyl butoxide , chemistry , mealworm , amide , stereochemistry , ether , moiety , diphenyl ether , organic chemistry , biochemistry , toxicity , larva , biology , botany
A number of compounds related to SKF 525A were tested for synergism with pyrethrins, using Lesser Mealworm beetles, Alphitobius laevigatus , and houseflies, Musca domestica , as test insects. SKF 525A had previously been shown to be active, whereas 2,2‐diphenyl‐n‐pentanoic acid and 2‐diethylaminoethanol were inactive. Several active compounds resulted from esterification of 2‐diethylaminoethanol with diphenylacetic acid and 1‐substituted diphenylacetic acids. Most modifications of the alcoholic moiety of active 2‐diethylaminoethyl esters destroyed activity. Active compounds resulted when a 2‐diethylamino group was joined to a diphenylmethyl group through an ester, ketone or ether linkage, but the analogous amide was inactive. 2‐Diethylaminoethyl piperonylate probably owed its activity to its piperonyl group. None of the compounds investigated approached piperonyl butoxide in synergistic activity.