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Insecticidal synergism with the pyrethrins: Studies on the relationship between chemical structure and synergistic activity in the 3 :4‐methylenedioxyphenyl compounds
Author(s) -
Moore B. P.,
Hewlett P. S.
Publication year - 1958
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740091007
Subject(s) - mode of action , methylene , chemistry , chemical structure , stereochemistry , toxicology , organic chemistry , biology , biochemistry
A series of 3 : 4‐methylenedioxyphenyl compounds of graded complexity have been synthesized and tested for synergism with the pyrethrins against adult Black Fungus beetles, Alphitobius laevigatus. The results establish the minimal molecular requirements for such synergism and point to the methylene group as the seat of activity. The effects of stepwise modification of the minimal synergist molecule are considered in the light of current theories of the mode of action.