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Studies in selective toxicity. III. —Benzenesulphonanilides as DDT‐synergists
Author(s) -
Neeman M.,
Mer G. G.,
Cwilich R.,
Modiano A.,
Zacks S.
Publication year - 1957
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740080109
Subject(s) - halogen , chemistry , homologous series , toxicant , alkyl , kerosene , solubility , toxicity , limiting , penetration (warfare) , organic chemistry , medicinal chemistry , stereochemistry , mechanical engineering , operations research , engineering
Abstract Benzenesulphonanilides with halogen or methyl substituents in the phenyl radicals, with or without N ‐alkyl substituents, were assayed as DDT‐synergists against DDT‐resistant houseflies. Contrasting test methods provided a guide to the intrinsic biological activity of the synergists, and to their ‘availability’ for insects by pick‐up from residual deposits and by absorption through the cuticle. The homologous series of N ‐ n ‐alkyl‐4‐chloro‐ and ‐4‐bromo‐benzenesulphon‐4′‐chloro‐anilides were studied. In both series the biological response to topical application of dilute toxicant solutions was highest for the N ‐methyl compounds. The ‘availability’ from deposits appeared highest in the intermediate range C 4 to C 8 . In this range the ‘availability’ appeared to oscillate between homologues having an odd number and those having an even number of carbon atoms. The homologues in the medium range showed a high solubility in kerosene. Homologues above C 9 showed no biological activity. The possible modes of action and penetration of the benzenesulphonanilide synergists are discussed.