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Studies on the blood proteins of hyperimmune horses. I.—The effect of high concentrations of phenolic substances on the proteins of plasma
Author(s) -
Harms A. J.
Publication year - 1953
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740040201
Subject(s) - hyperimmunization , chemistry , blood proteins , albumin , salt (chemistry) , antibody , chromatography , bovine serum albumin , biochemistry , organic chemistry , biology , immunology
Work carried out on the combination of plasma proteins with higher concentrations of phenolic substances than those normally used for preservation has indicated the formation of easily dissociated complexes. The complex formed with albumin is very much less soluble in neutral salt solutions than the original protein. This observation has formed the basis for a new process for the purification of antitoxic and antibacterial sera, and this process is described. The bearing of the results on the formation of antibodies during the hyperimmunization of horses is discussed.