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The fate of labelled insecticide residues in food products. I.—Studies with a radioactive bromine analogue of DDT
Author(s) -
Winteringham F. P. W.,
Harrison A.,
Jones C. R.,
McGirr J. L.,
Templeton W. H.
Publication year - 1950
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.2740010707
Subject(s) - metabolite , bromine , chemistry , ingestion , acetic acid , food science , pesticide , toxicology , environmental chemistry , radiochemistry , biology , organic chemistry , biochemistry , agronomy
A radioactive bromine analogue, 1:1:1‐trichloro‐2:2‐di‐(4‐bromophenyl)ethane, of the insecticide DDT has been used to indicate the fate of DDT sprayed on to wheat grain which is subsequently milled, baked and fed to animals. 82 Br of high specific activity was prepared in the Harwell pile by the Szilard‐Chalmers method and was used for the synthesis of the analogue. Grain carrying 402 p.p.m. of the labelled insecticide was milled under typical conditions. A concentration of 14.6 p.p.m. was found in the flour (85% extraction) and 11.2 p.p.m. in bread made from the flour. There was evidence that some of the insecticide was in a ‐combined form in the bread. Some of the grain and bread were fed to hens and rats respectively. The insecticide was found in all the tissues examined. A fraction of the radioactivity found in the excreta behaved as the di‐(4‐bromo‐phenyl)acetic acid metabolite. This metabolite was identified in the urine of a man following ingestion of some of the bread.