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Antihyperlipidaemic effect of Aegle marmelos fruit extract in streptozotocin‐induced diabetes in rats
Author(s) -
Kamalakkannan N,
Stanely Mainzen Prince P
Publication year - 2005
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.1978
Subject(s) - streptozotocin , glibenclamide , diabetes mellitus , intraperitoneal injection , oral administration , chemistry , pharmacology , aqueous extract , traditional medicine , medicine , endocrinology
Abstract The present study determines the effect of an aqueous extract of Aegle marmelos fruits on serum and tissue lipids in experimental diabetes. Albino Wistar rats were rendered diabetic by intraperitoneal administration of streptozotocin (45 mg kg −1 ). Serum and tissue lipids such as total cholesterol, triglycerides, free fatty acids and phospholipids were elevated in diabetic rats. Oral administration of A marmelos fruit extract at doses of 125 and 250 mg kg −1 to diabetic rats twice daily for 1 month led to a significant lowering of these lipids in diabetic rats. The effect exerted by the fruit extract at a dose of 250 mg kg −1 was greater than that of the dose of 125 mg kg −1 or of glibenclamide (300 µg kg −1 ). The results of this study demonstrate that an aqueous A marmelos fruit extract exhibits an antihyperlipidaemic effect in streptozotocin‐induced diabetic rats. Copyright © 2004 Society of Chemical Industry