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Predicting in silico bioprocess additive and food additive undesirable outcomes due to utilising cytochrome P450 isoform metallomimics
Author(s) -
Wiseman Alan
Publication year - 2004
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.1692
Subject(s) - bioprocess , in silico , cytochrome p450 , gene isoform , biotransformation , biochemistry , computational biology , chemistry , isozyme , enzyme , microbiology and biotechnology , biochemical engineering , biology , gene , engineering , paleontology
Up to 2700 isoforms of cytochromes P450 bioconvert components of food bioprocessing. Nutragenomics define the biotransformation abilities of particular cytochromes P450 selected from 57 human isoforms in appropriate tissues such as the liver. Safety predictions solely in silico are unreliable using metallomimics of the Fe‐containing enzymes. Copyright © 2004 Society of Chemical Industry