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Metabolic regulation mechanism of fucoidan via intestinal microecology in diseases
Author(s) -
Sun Ting,
Xue Meilan,
Yang Jia,
Pei Zhongqian,
Zhang Nan,
Qin Kunpeng,
Liang Hui
Publication year - 2021
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.11202
Subject(s) - microecology , fucoidan , fucose , intestinal mucosa , prebiotic , immune system , monosaccharide , gut flora , intestinal disorder , biology , polysaccharide , biochemistry , microbiology and biotechnology , immunology , galactose , medicine , disease
The intestinal microecology is an extremely complex ecosystem consisting of gut microbiota, intestinal mucosa and the intestinal immune system. The intestinal microecology performs several important functions and is considered to be an essential ‘organ’ because it plays an important role in regulating human metabolism. Fucoidan contains a large amount of fucose and galactose residues, as well as various other neutral and acidic monosaccharides. Fucoidan particularly effects tumors, inflammatory bowel disease, diabetes and obesity by repairing intestinal mucosal damage and improving the intestinal microecological environment. It has been proposed that fucoidan could be used as a prebiotic agent for pharmaceutical and functional foods. In this review, we elucidate the potential mechanisms of the metabolic regulation of fucoidan with respect to the intestinal microecology of diseases. © 2021 Society of Chemical Industry