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Effect of Momordica saponin‑ and Cyclocarya paliurus polysaccharide‐enriched beverages on oxidative stress and fat accumulation in Caenorhabditis elegans
Author(s) -
Lin Chunxiu,
Lin Yizi,
Xiao Jie,
Lan Yaqi,
Cao Yong,
Chen Yunjiao
Publication year - 2021
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.10966
Subject(s) - momordica , oxidative stress , caenorhabditis elegans , reactive oxygen species , antioxidant , saponin , malondialdehyde , chemistry , food science , polysaccharide , pharmacology , biochemistry , traditional medicine , biology , medicine , gene , alternative medicine , pathology
BACKGROUND As an edible and medicinal herb in Chinese folk medicine, Cyclocarya paliurus (Batal.) Iljinskaja leaves are traditionally widely used in the treatment of metabolic disorders. The vegetable Momordica charantia L. has been consumed worldwide for thousands of years as a traditional drug due to its activities against obesity and diabetes. In view of the therapeutic value of Momordica saponins (MSs) and C. paliurus polysaccharides (CPPs), an independently developed MSs‑ and CPPs‐containing beverage (MC) was evaluated for its efficacy in controlling oxidative stress and obesity in Caenorhabditis elegans . RESULTS First, we found that MC could promote the nuclear localization of DAF‐16 and the translation of SOD‐3. Further exploring its antioxidant properties, the oxidative stress by‐products reactive oxygen species, malondialdehyde, and nonesterified fatty acids were significantly inhibited in C. elegans . Moreover, damage due to diseases related to oxidative stress (age pigments and neurodegenerative diseases) was alleviated. Furthermore, fat accumulation was significantly reduced in normal and high‐fat models. Finally, the lipid‐lowering effects of MC might involve reductions in the size and number of lipid droplets without impairing basic physiological functions in C. elegans . CONCLUSION These results provide promising data indicating MC as an innovative health beverage for the pharmacological management of oxidative stress and obesity. © 2020 Society of Chemical Industry.