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Effects of circadian iron administration on iron bioavailability and biological rhythm in pigs
Author(s) -
Dong Zhenglin,
Li Lan,
Zhang Yiming,
Guo Liu,
Wu Xin,
Yin Yulong,
Wan Dan
Publication year - 2021
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.10897
Subject(s) - circadian rhythm , hepcidin , endocrinology , medicine , bioavailability , dmt1 , duodenum , oral administration , metabolism , chemistry , biology , biochemistry , anemia , pharmacology , transporter , gene
BACKGROUND Iron supplements are limited by their poor absorption and low efficacy. A circadian feeding schedule would affect the circadian rhythm and improve nutrient metabolism. In this study, 18 iron‐deficient piglets were randomly assigned to three groups: a control group receiving a constant diet with mid‐iron (MI), a ‘HL’ group receiving a high‐iron (HI) diet at 8:00 h and a low‐iron (LI) diet at 18:00, and an ‘LH’ group receiving a LI diet at 8:00 and a HI diet at 18:00. The effects of circadian iron administration on iron absorption, iron status, and biological rhythm in iron‐deficient piglets were investigated. RESULTS Serum iron and hemoglobin improved significantly ( P < 0.05) but did not significantly differ in the circadian iron‐feeding groups ( P > 0.05). Iron concentration in the liver and spleen was significantly higher in the LH group than in the HL group ( P < 0.05), and mRNA expression of divalent metal transport 1 (DMT1), cytochrome B (CYBRD1) and ferroportin (FPN) genes in the duodenum was significantly elevated in the LH group ( P < 0.05). The clock‐related genes showed differential expression in the duodenum, with greater mRNA expression for period (Per2) and cryptochrome (Cry1 and Cry2) in the LH group ( P < 0.05). CONCLUSION Circadian iron administration affected iron absorption and iron storage in pigs. Iron supplementation in the evening might be a more effective pattern for iron utilization. The rhythmic system in the intestine, driven by the time, played an important role in this process. © 2020 Society of Chemical Industry