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Effects of different concentrations of coated nano zinc oxide material on fecal bacterial composition and intestinal barrier in weaned piglets
Author(s) -
Liu Hongnan,
Bai Miaomiao,
Xu Kang,
Zhou Jian,
Zhang Xiaofeng,
Yu Rong,
Huang Ruilin,
Yin Yulong
Publication year - 2020
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.10686
Subject(s) - occludin , lachnospiraceae , zinc , chemistry , barrier function , feces , gut flora , food science , composition (language) , biochemistry , microbiology and biotechnology , biology , tight junction , firmicutes , linguistics , philosophy , 16s ribosomal rna , organic chemistry , gene
BACKGROUND Coated nano zinc oxide (Cnz) is a new feed or food additive, which is a potential replacement for a pharmacological dose level of ZnO. This study evaluated the positive effects of different concentrations of Cnz on the intestinal bacterial core, enterobacterial composition and mucosal barrier function in a pig model. RESULTS Microbiota sequencing results showed that Cnz could significantly alter the intestinal microbiota composition and metabolism. Besides increasing the richness indices (ACE and Chao1), 10% Cnz could protect the intestinal mucosal barrier through increasing the expression of occludin and zonula occludens‐1 in the small intestine, increase the abundance of Lachnospiraceae UCG‐004 and decrease the abundance of Ruminococcus flavefaciens compared to high ZnO diet and 5% Cnz material. CONCLUSIONS Cnz material at 10% supplementation is more effective than a level of 5% Cnz in increasing intestinal barrier through affecting gut microbiota. © 2020 Society of Chemical Industry