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No association between dietary acrylamide and renal cell carcinoma: an updated meta‐analysis
Author(s) -
Jiang Feng,
Teng Min,
Zhu YanXin,
Li YongJie
Publication year - 2020
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.10339
Subject(s) - acrylamide , renal cell carcinoma , meta analysis , medicine , relative risk , confidence interval , carcinoma , epidemiology , kidney cancer , kidney , oncology , chemistry , organic chemistry , copolymer , polymer
BACKGROUND The relationship between dietary acrylamide intake and renal cell carcinoma risk is inconclusive. In consideration of the recent findings, we conducted an updated meta‐analysis to assess the association between acrylamide intake and renal cell carcinoma risk. RESULTS PubMed, EMBASE, and Cochrane databases have been used to identify epidemiological studies on dietary acrylamide intake and renal cell carcinoma risk. This meta‐analysis study included eight studies, 2843 cases, and 309 920 controls/participants. We performed meta‐analyses to calculate the summary relative risk (RR) for the highest versus lowest intake of dietary acrylamide. No meaningful association was found for renal cell carcinoma; RR was 1.12 (95% confidence interval (CI): 0.97–1.28). Among participants who never smoked, no association was found between dietary acrylamide and renal cell carcinoma; the RR for highest versus lowest intake of dietary acrylamide was 1.11 (95% CI: 0.93–1.32). CONCLUSION This meta‐analysis study indicates that dietary acrylamide is not related to the risk of renal cell carcinoma. © 2020 Society of Chemical Industry