Premium
Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: a randomized crossover trial
Author(s) -
Barati Boldaji Reza,
Akhlaghi Masoumeh,
Sagheb Mohammad Mahdi,
Esmaeilinezhad Zahra
Publication year - 2019
Publication title -
journal of the science of food and agriculture
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 142
eISSN - 1097-0010
pISSN - 0022-5142
DOI - 10.1002/jsfa.10096
Subject(s) - hemodialysis , oxidative stress , crossover study , medicine , malondialdehyde , blood pressure , lipid profile , lipoprotein , cholesterol , antioxidant , low density lipoprotein , blood lipids , high density lipoprotein , endocrinology , gastroenterology , chemistry , biochemistry , pathology , alternative medicine , placebo
BACKGROUND Pomegranate has antioxidant, cardioprotective and anti‐inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty‐one hemodialysis patients were randomly assigned to one of two groups: PJ‐treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4‐week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention‐to‐treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high‐density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low‐density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition ( P < 0.001) and decreased in the controls ( P < 0.001). Conversely, malondialdehyde and interleukin‐6 decreased in PJ ( P < 0.001) and increased in the control group ( P ≤ 0.001). The changes of these biomarkers were significantly different between the two conditions. CONCLUSIONS Eight‐week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high‐density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. © 2019 Society of Chemical Industry