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Synthesis and Characterization of Fluorescent Surfactants for Studying the Penetration of Cosmetic Surfactants on the Skin
Author(s) -
Kong Shuai,
Shen Chong,
Luo Yulu,
Meng Qin
Publication year - 2020
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1002/jsde.12416
Subject(s) - pulmonary surfactant , cosmetics , penetration (warfare) , chemistry , fluorescence , solvent , fluorescein , chromatography , chemical engineering , organic chemistry , biochemistry , physics , operations research , engineering , quantum mechanics
Surfactants are one of the important ingredients of cosmetics. However, their penetration and penetration‐promoting behavior in the skin has not been well understood. Aiming to explore the surfactant penetration in skin, a novel fluorescent surfactant F‐C16, based on sodium fluorescein, was synthesized in this paper. F‐C16 has a fluorescence maxima ( λ em ) of around 530 nm, and its fluorescence increased with the polarity of solvent. It possesses good emulsifying properties and low cytotoxicity. Hence, it can be used as a quickly detected indicator for surfactants in cosmetics. As demonstrated by this fluorescent surfactant, it was found that the surfactants can penetrate well into skin and cells. It seems that surfactants in cosmetics can enter the cells and reach the dermal layer of skin.