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Nonionic Isatin Surfactants: Synthesis, Quantum Chemical Calculations, ADMET and Their Antimicrobial Activities
Author(s) -
Hussein Ahmed M.,
Khowdiary Manal M.
Publication year - 2020
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1002/jsde.12379
Subject(s) - chemistry , isatin , chloroacetic acid , ethylene glycol , pulmonary surfactant , biodegradation , antimicrobial , fourier transform infrared spectroscopy , ethylene oxide , organic chemistry , molecule , biological activity , proton nmr , chemical engineering , polymer , biochemistry , engineering , copolymer , in vitro
The most challenge task in the building up of surface‐active molecules is maximizing their surface activity with good biological activity. A nonionic surfactant ( N ‐isatin‐EO m ‐C n where m is 5, 7 and 9 ethylene glycol units and n is 8, 10 and 12) is achieved by first reacting isatin with chloroacetic acid and then with different types of ethoxylated (C 8 –C 12 ) fatty alcohols that possess 5, 7 and 9 ethylene oxide units. The prepared surfactants were characterized by FTIR and 1 H NMR to confirm the structure. The surface activity, biodegradability, antimicrobial, and antifungal activity of the surfactants were evaluated. In addition, quantum chemical calculations and computations of oral bioavailability were performed. The obtained data show that all the synthesized compounds had good surface activity, biodegradability and biological activity.