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Synthesis of Triazole‐Based Nonionic Surfactants for Nanostructured Drug Delivery: Investigation of Their Physicochemical and Biological Aspects
Author(s) -
Alam Faima,
Khan Momin,
Ateeq Muhammad
Publication year - 2019
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1002/jsde.12326
Subject(s) - chemistry , biocompatibility , drug delivery , critical micelle concentration , micelle , biocompatible material , combinatorial chemistry , organic chemistry , nanotechnology , materials science , biomedical engineering , medicine , aqueous solution
Synthesis of novel nonionic surfactants has attracted attention of synthetic chemists due to the issues of the currently used commercial surfactants. The synthesis of three biocompatible triazole‐based nonionic surfactants is reported for nanovesicular drug loading. The surfactants were synthesized in a three‐step reaction and characterized using 1 HNMR and mass spectroscopy techniques. They were investigated for their critical micelle concentration (CMC) using a UV–Visible spectrophotometer. Their biocompatibility was investigated against cell culture and in blood. All the synthesized nonionic surfactants were further explored for their nanovesicular drug loading using clarithromycin as a model hydrophobic drug. Nonionic surfactants revealed lower CMC in 35–45 μM and were less hemolytic and cytotoxic. They were capable of self‐assembling in nanosize niosomal vesicles encapsulating increased amounts of drug. The results suggest the synthesized nonionic surfactants as biocompatible nanotechnology‐based drug‐delivery vehicles.