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Synthesis, Characterization, and Micellization Behavior of Cationic Surfactants: n‐Alkyl‐3‐Methylpyridinium Bromides and Their Drug Interaction Study by UV–Visible Spectroscopy and Conductometry
Author(s) -
Fayyaz Summaira,
Talat Rabia,
Ali Saqib,
Khalid Nasir,
Shah Afzal,
Ullah Faizan
Publication year - 2019
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1002/jsde.12263
Subject(s) - chemistry , conductometry , cationic polymerization , bromide , critical micelle concentration , micelle , ultraviolet visible spectroscopy , pulmonary surfactant , fourier transform infrared spectroscopy , spectroscopy , infrared spectroscopy , alkyl , nuclear magnetic resonance spectroscopy , ketoprofen , nuclear chemistry , organic chemistry , inorganic chemistry , aqueous solution , chemical engineering , chromatography , biochemistry , physics , quantum mechanics , engineering
The synthesis of new cationic surfactants i.e., n‐hexyl‐3‐methylpyridium bromide ( a ) and n‐octyl‐3‐methylpyridium bromide ( b ), and their characterization using multinuclear nuclear magnetic resonance spectroscopy (NMR) ( 1 H, 13 C) and Fourier‐transform infrared spectroscopy (FT‐IR) spectroscopic techniques were reported. The micellization behavior of the synthesized surfactants was studied using conductometry and ultraviolet–Visible spectroscopy. The critical micelle concentration (CMC) of compounds a and b was found to be 0.41 and 0.35 m mol L −1 , respectively. The effect of temperature on the CMC of these compounds was examined in the range of 298–318 K and thermodynamic parameters (ΔG, ΔH, and ΔS) of the micellization process were calculated. The antibacterial study of the synthesized surfactants revealed their strong activity against different bacterial strains. Moreover, the interaction of drugs i.e., flurbiprofen and ketoprofen, with the synthesized surfactants was investigated for gaining insights into the role of micelles as drug‐delivery devices. Drug–surfactant interactions were also confirmed via a conductometric method.