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Hydrolytic Dephosphorylation of p‐ Nitrophenyl Diphenyl Phosphate by Alkyl Hydroxamate Ions
Author(s) -
Kandpal Neha,
Dewangan Hitesh K.,
Nagwanshi Rekha,
Ghosh Kallol K.,
Satnami Manmohan L.
Publication year - 2018
Publication title -
journal of surfactants and detergents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.349
H-Index - 48
eISSN - 1558-9293
pISSN - 1097-3958
DOI - 10.1002/jsde.12006
Subject(s) - chemistry , hydrolysis , bromide , vesicle , kinetics , phosphate , alkyl , inorganic chemistry , medicinal chemistry , nuclear chemistry , ion , dephosphorylation , organic chemistry , membrane , enzyme , biochemistry , phosphatase , physics , quantum mechanics
The kinetics of the hydrolysis of p ‐nitrophenyl diphenyl phosphate (PNPDPP) by hydroxamate ions (R'(CO)N(RO − ) such as octanohydroxamate (OHA − ) and decanohydroxamate (DHA − ) was investigated in dioctadecyldimethylammonium chloride (DODAC) and didodecyldimethylammonium bromide (DDAB) vesicles. The physicochemical properties of these surfactants were studied by conductivity and fluorescence measurements at 300 K. The hydrolysis of PNPDPP was studied in a vesicular system by using hydroxamate ions (OHA − and DHA − ) at 300 K. The different catalytic effects of hydroxamate ions for the hydrolysis of PNPDPP in the vesicles were determined. All reactions followed pseudofirst‐order kinetics. The reactivity of DHA − was found to be higher than that of OHA − in the vesicular system toward the cleavage of phosphate ester. Further, the binding constants ( K ) and free energy change (∆ G ) for the associations of PNPDPP with DODAC and DDAB vesicles were determined spectrophotometrically as well as from the Benesi–Hildebrand (B–H) plots. The pseudophase model was applied for the quantitative treatment of the kinetic data in the vesicle systems.