Near‐infrared multichannel Raman spectroscopy toward real‐time  in vivo  cancer diagnosis | Zendy

Kaminaka Shoji | Zendy; Ito Toshiaki | Zendy; Yamazaki Hiroya | Zendy; Kohda Ehiichi | Zendy; Hamaguchi Hiroo | Zendy

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Near‐infrared multichannel Raman spectroscopy toward real‐time in vivo cancer diagnosis

Author(s) -

Kaminaka Shoji,

Ito Toshiaki,

Yamazaki Hiroya,

Kohda Ehiichi,

Hamaguchi Hiroo

Publication year - 2002

Publication title -

journal of raman spectroscopy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.748

H-Index - 110

eISSN - 1097-4555

pISSN - 0377-0486

DOI - 10.1002/jrs.903

Subject(s) - raman spectroscopy , in vivo , spectroscopy , fluorescence , near infrared spectroscopy , infrared , raman scattering , human lung , interference (communication) , chemistry , materials science , optics , optoelectronics , lung , biology , medicine , computer science , physics , telecommunications , microbiology and biotechnology , quantum mechanics , channel (broadcasting)

Using a newly developed InP/InGaAsP multichannel detector, we developed a near‐infrared Raman spectroscopic system that can measure human tissues efficiently without interference from fluorescence. This enabled us to measure an in vivo Raman spectrum of live human tissue (skin) in 1 min using fiber probe optics. By applying this system to human lung tissues, we found that Raman spectroscopy makes a clear distinction not only between normal and cancerous tissues but also between two different types of lung carcinomas. The results indicate a promising future for the non‐invasive real‐time Raman diagnosis of cancers. Copyright © 2002 John Wiley & Sons, Ltd.

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