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Conformational study of AZT in aqueous solution and adsorbed on a silver surface by means of Raman spectroscopy
Author(s) -
Rivas Laura,
SanchezCortes Santiago,
GarcíaRamos José V.
Publication year - 2002
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.802
Subject(s) - raman spectroscopy , adsorption , chemistry , aqueous solution , surface enhanced raman spectroscopy , deprotonation , thymine , conformational isomerism , spectroscopy , crystallography , inorganic chemistry , molecule , organic chemistry , raman scattering , dna , biochemistry , ion , physics , quantum mechanics , optics
The adsorption and conformation of the anti‐HIV drug AZT, and also thymine and 2′‐deoxythymidine, were studied on Ag colloids by surface‐enhanced Raman spectroscopy, showing that the conformational change induced by the adsorption on an Ag surface is similar to that induced by an alkaline pH, both related to deprotonation of the N‐3 atom leading to the C‐3′‐ endo conformer. Copyright © 2002 John Wiley & Sons, Ltd.