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Volumetric Raman chemical imaging of drug delivery systems
Author(s) -
Slipets Roman,
Ilchenko Oleksii,
Mazzoni Chiara,
Tentor Fabio,
Nielsen Line Hagner,
Boisen Anja
Publication year - 2020
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.5869
Subject(s) - drug delivery , raman spectroscopy , materials science , coating , nanotechnology , transparency (behavior) , raman microspectroscopy , polymer , drug , biomedical engineering , computer science , optics , composite material , medicine , physics , computer security , psychiatry
The ability to image drug distribution inside a several hundred micron thick polymer matrix, encapsulated by a protective coating, would greatly contribute to the understanding of the performance and shortcomings of drug delivery devices. Here, we present an experimental framework for deep volumetric Raman imaging (dVRI), where common challenges such as low Raman cross section, fluorescence, and low transparency of samples are overcome. We apply dVRI to a selection of drug delivery forms, tablets with thin protective coatings and drug‐loaded microdevices. We demonstrate three‐dimensional visualization of the different drug/polymeric materials, constituting a drug delivery device, with imaging depth of 225 μm.