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A sensitive resonance Rayleigh scattering sensor for dopamine in urine using upconversion nanoparticles
Author(s) -
Murillo Pulgarín José Antonio,
Alañón Molina Aurelia,
Jiménez García Elisa,
García Gómez Lucía
Publication year - 2020
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.5800
Subject(s) - detection limit , photon upconversion , chemistry , rayleigh scattering , raman scattering , dopamine , analyte , analytical chemistry (journal) , resonance (particle physics) , biosensor , chromatography , materials science , raman spectroscopy , ion , organic chemistry , optics , biochemistry , physics , particle physics , neuroscience , biology
Abstract A highly sensitive resonance light scattering method for detecting dopamine in urine was developed by using a novel probe based on lanthanide‐doped upconversion nanoparticles (UCNPs) linked to dopamine–quinone (DQ) by hydrogen bonding and electrostatic interactions. Adding dopamine to a solution containing UCNPs decreases their size and the intensity of their resonance light scattering signals. Based on the decrease, dopamine can be determined in Tris–HCl buffer and in urine samples spiked with analyte concentrations over the range 0–300 μM with a limit of detection of 1.62 μM. As‐prepared UD can thus provide an effective platform for biosensor development, drug discovery, and rapid diagnosis of Parkinson's and Alzheimer's disease, among other medical conditions.