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Siliceous‐based monolithic materials coated with a hydroxyapatite layer: Preparation and investigation of drug affinity by Raman spectroscopy
Author(s) -
Zielińska Monika,
Buchwald Tomasz,
Marańda Monika,
Voelkel Adam
Publication year - 2019
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.5682
Subject(s) - raman spectroscopy , materials science , sorption , ceramic , chemical engineering , desorption , energy dispersive x ray spectroscopy , scanning electron microscope , spectroscopy , nuclear chemistry , composite material , adsorption , chemistry , organic chemistry , physics , quantum mechanics , optics , engineering
Monolithic materials based on silica and hydroxyapatite was applied as tool for investigation of interactions between bone and potential antiresorptive drugs. First type of material was created on the basis of tetramethyl orthosilicate and trimethoxymethylsilane. Second type of material contained additionally chitosan in its structure. Ceramic fraction of monoliths was prepared in two ways: by incorporation of hydroxyapatite during crosslinking or by using soaking method (hydroxyapatite mineralization on the surface). Monolithic materials were prepared in two different forms: in the form of a cylinder and as a filling of a needle for monolithic in‐needle extraction (MINE) device. Several techniques were applied to evaluate the properties of 19 prepared materials: energy dispersive X‐ray spectroscopy, scanning electron microscopy, and Raman spectroscopy, which allowed to confirm and characterize occurred hydroxyapatite layer. Sorption–desorption investigation, with the sodium risedronate as test compound, was made with using ultraviolet‐visible spectroscopy, to assess the affinity of the bisphosphonate for the ceramic layer of the material as a bone substitute. One of 15 prepared MINE devices exhibits sorption ability of risedronate equal to 97%.