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Gold‐patterned microarray chips for ultrasensitive surface‐enhanced Raman scattering detection of ultratrace samples
Author(s) -
Chen Si,
Guo Zhinan,
Sang David K.,
Wang Huide,
Xu Yanhua,
Tang Siying,
Luo Qian,
Cao Rui,
Wang Xiaolei,
Zhang Ling,
Liao Jianghai,
Zhang Han,
Yu XueFeng,
Zhao Bing,
Fan Dianyuan
Publication year - 2019
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.5506
Subject(s) - rhodamine 6g , raman scattering , materials science , detection limit , surface enhanced raman spectroscopy , nanotechnology , raman spectroscopy , chemistry , analytical chemistry (journal) , chromatography , optics , molecule , physics , organic chemistry
This paper reports the fabrication of gold‐patterned microarray chips for fast and ultrasensitive surface enhanced Raman scattering (SERS) detection of trace samples. By micro‐nano machining based on electron‐beam lithography, magnetron sputtering, and chemical modification, gold‐patterned microarray chips with hydrophilic and hydrophobic periodic structures are fabricated, and a polyethylene glycol (PEG) layer is coated on the surface of the gold well, making the chips long‐term stable. The hydrophilic surface of each gold well is surrounded by a hydrophobic layer, which makes the ultratrace sample amount for SERS measurement only 0.3 μl. In the detection of malachite green (MG), 4‐mercaptopyridine (4‐MPY), rhodamine 6G (R6G), and melamine, great enhanced SERS signals with the detection limit reaching nM level can be achieved due to the enrichment effect of the periodic structures and the hot‐spots generated between the sandwich structure built on the gold wells. Such gold‐patterned microarray chip is promising in fast and ultrasensitive SERS detection of various chemical and biological species with trace amount.