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Drop‐coating deposition Raman spectroscopy of porphyrins
Author(s) -
Kočišová Eva,
Procházka Marek
Publication year - 2015
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.4637
Subject(s) - raman spectroscopy , porphyrin , resonance raman spectroscopy , analytical chemistry (journal) , raman scattering , spectroscopy , chemistry , drop (telecommunication) , surface enhanced raman spectroscopy , protoporphyrin ix , deposition (geology) , materials science , photochemistry , optics , chromatography , organic chemistry , photodynamic therapy , telecommunications , paleontology , physics , quantum mechanics , sediment , computer science , biology
We report an improvement of the Raman detection sensitivity of porphyrins by factor of 10 5 using drop‐coating deposition Raman spectroscopy (DCDR). We were able to obtain Raman spectra from ~20 nM initial (deposited) concentrations of cationic and anionic porphyrin. This detection limit is comparable with or even better than that of surface‐enhanced Raman scattering spectroscopy using Ag nanoparticles. Moreover, DCDR spectrum of protoporphyrin IX, which is known as a marker in clinical diagnostics of cancer, was also obtained from 10 nM deposited concentration. To our knowledge, it is the first demonstration of the resonance DCDR spectroscopy. Copyright © 2015 John Wiley & Sons, Ltd.