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Preparation and characterization of poly(lactic acid)/poly(methyl methacrylate) blend tablets for application in quantitative analysis by micro Raman spectroscopy
Author(s) -
VanoHerrera Kelim,
Misiun Anna,
Vogt Carla
Publication year - 2015
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.4603
Subject(s) - poly(methyl methacrylate) , materials science , differential scanning calorimetry , glass transition , raman spectroscopy , methyl methacrylate , polylactic acid , amorphous solid , lactic acid , analytical chemistry (journal) , methacrylate , polymer , polymer chemistry , biodegradable polymer , dissolution , calibration curve , polymer blend , chemical engineering , monomer , detection limit , composite material , chemistry , organic chemistry , chromatography , copolymer , physics , genetics , biology , bacteria , optics , thermodynamics , engineering
Poly(lactic acid) (PLA) is a biodegradable polymer that has a variety of applications, one of which is as biomaterial in surgery or as functional layers on implants, due to its compatibility with living tissue. This paper reports the possibilities of quantification of poly(lactic acid) (PLA) in a polymer matrix such as poly(methyl methacrylate) (PMMA) by micro Raman spectroscopy (MRS). Blends of amorphous poly(DL‐lactic acid) with poly(methyl methacrylate) were prepared by the procedure of dissolution/precipitation. Thermal properties of the blends such as the glass transition temperature ( Tg ) were characterized by differential scanning calorimetry (DSC). The PLA/PMMA blends exhibited only a single glass transition region, indicating that this system is miscible. The PLA/PMMA system obeys the Gordon–Taylor equation ( Tg versus PLA content). Various concentration ratios of PLA blends were prepared to use as a basis for quantitative analysis by MRS. Intensities of the characteristic bands at 813 cm −1 (νCOC of PMMA) and 873 cm −1 (νC―COO of PLA) were used for the calculation. The calibration graph showed a good linear correlation with an R 2 value of 0.9985. On the basis of the calibration curve obtained, the determined content of several PLA/PMMA blends was in good agreement when compared with nominal contents. The limit of detection (LOD) and quantification (LOQ) were calculated by the calibration data set as signal‐to‐noise method. The relative standard deviation of this method was lower than 10% and the accuracy better than 4%. This study demonstrated that Raman spectroscopy provides an alternative non destructive method for quantitative analysis of PLA in a PMMA matrix. Copyright © 2015 John Wiley & Sons, Ltd.