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Noninvasive monitoring of photocatalytic degradation of X‐ray contrast media using Raman spectrometry
Author(s) -
Salkic Sabina,
Eckler Logan H.,
Nee Matthew J.
Publication year - 2013
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.4389
Subject(s) - raman spectroscopy , degradation (telecommunications) , iohexol , photocatalysis , chemistry , aqueous solution , mass spectrometry , diatrizoate , analytical chemistry (journal) , photochemistry , environmental chemistry , chromatography , computer science , optics , catalysis , organic chemistry , physics , telecommunications , renal function , biochemistry
The photocatalytic degradation of the X‐ray contrast agents iohexol and diatrizoate are monitored by in situ Raman spectrometry measurements in aqueous solution with a TiO 2 photocatalyst. Spectral features and changes are interpreted with the use of density functional theory calculations. While we observe similar results to those published previously, significant changes seen in the Raman spectrum allow us to better identify the mechanisms without the need for deductive approaches or complicated sample preparation. Diatrizoate spectra are consistent with hydroxyl radical attack leading to the loss of CO 2 . Iohexol is more difficult to interpret, representing a current challenge to the use of Raman spectrometry for real‐time monitoring of photocatalytic degradation experiments. We explore internal standards that can be added to gauge overall degradation rates to some extent. Potential extensions of the work are described, particularly in terms of increased rate of data acquisition and more general application. Copyright © 2013 John Wiley & Sons, Ltd.