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B 2 bradykinin receptor antagonists: adsorption mechanism on electrochemically roughened Ag substrate
Author(s) -
Proniewicz Edyta,
Skołuba Dominika,
Kudelski Andrzej,
Sobolewski Dariusz,
Prahl Adam,
Kim Younkyoo,
Proniewicz Leonard M.
Publication year - 2013
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.4182
Subject(s) - chemistry , substrate (aquarium) , bradykinin , raman spectroscopy , raman scattering , molecule , adsorption , stereochemistry , crystallography , receptor , organic chemistry , biochemistry , optics , oceanography , physics , geology
In this paper, the surface‐enhanced Raman scattering (SERS) spectra of the potent B 2 bradykinin receptor antagonists, [D‐Arg 0 ,Hyp 3 ,Thi 5,8 ,L‐Pip 7 ]BK, Aaa[D‐Arg 0 ,Hyp 3 ,Thi 5,8 ,L‐Pip 7 ]BK, [D‐Arg 0 ,Hyp 3 ,Thi 5 ,D‐Phe 7 ,L‐Pip 8 ]BK, and Aaa[D‐Arg 0 ,Hyp 3 ,Thi 5 ,D‐Phe 7 ,L‐Pip 8 ]BK, were measured when immobilized onto a highly specific electrochemically roughened SERS‐active Ag substrate characterized by the formation of a 50 – 150 nm Ag islands on its surface. The observed SERS bands corresponding to different vibrational modes of the molecule, attached to or near Ag, and the variations in these bands resulting from competitive interactions of the functional groups of the peptides with the SERS‐active Ag surfaces and reorientation occurring over time of adsorption were analyzed in this study. Copyright © 2012 John Wiley & Sons, Ltd.