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Laser Raman spectroscopic investigations of biodegradable vehicle of active agents eluting LVM 316 stainless steel cardiovascular stents for in vivo degradation characteristics
Author(s) -
Sudheer S. K.,
Prathibha S.,
Kothwala D.,
Engineer C.,
Raval A.,
Jerriwala A. B.,
Kotadia H.
Publication year - 2010
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.2457
Subject(s) - polymer , biodegradable polymer , raman spectroscopy , materials science , polymer degradation , layer (electronics) , degradation (telecommunications) , stent , biodegradation , conjugated system , laser , nanotechnology , biomedical engineering , chemical engineering , composite material , chemistry , surgery , organic chemistry , optics , medicine , computer science , telecommunications , engineering , physics
Laser Raman spectroscopy is an effective tool for the study of biodegradable polymers, which play a vital role in the new developments in coronary implants such as stents. There is much excitement around the potential capabilities of synthetic biodegradable polymers and the effect they will have on the design and function of implanted devices. In the present investigation, heparin‐conjugated biodegradable copolymers were evaluated for their durability as drug‐eluting stent coatings. Laser Raman spectroscopic studies were carried out and spectra recorded and analyzed of explanted stents coated with different amounts of polymer alone, showing the existence of different levels at different quantities of polymer. The polymer was detected on every stent analyzed. On the stents coated with a thick layer of polymer, a firm layer of polymer still existed on the stent. In contrast, this layer was degraded and spread around on the stents coated with only a thin layer of the polymer. This indicates that the polymers used in the stents in the present investigation exhibit acceptable biodegradability. Such polymers can be used as efficient drug carriers, as these materials show good degradation after the stipulated period. Copyright © 2009 John Wiley & Sons, Ltd.