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Towards a rational drug design: Raman micro‐spectroscopy analysis of prostate cancer cells treated with an aqueous extract of Nerium Oleander
Author(s) -
Saha A.,
Yakovlev V. V.
Publication year - 2009
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.2302
Subject(s) - raman spectroscopy , prostate cancer , aqueous solution , aqueous extract , cancer cell , surface enhanced raman spectroscopy , chemistry , drug , rational design , traditional medicine , materials science , cancer , medicine , pharmacology , raman scattering , nanotechnology , organic chemistry , optics , physics
Raman spectroscopy is an efficient optical technique used to identify and grade cancer on the basis of the molecular composition of the cell. In this work Raman spectroscopy is used to study the chemical alteration occurring inside a prostate cancer cell as a result of a treatment with a low‐concentration aqueous extract of Nerium Oleander . The results show that Nerium Oleander affects the protein and lipid concentration of cancer cells. Copyright © 2009 John Wiley & Sons, Ltd.