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Raman to the limit: tip‐enhanced Raman spectroscopic investigations of a single tobacco mosaic virus
Author(s) -
Cialla Dana,
DeckertGaudig Tanja,
Budich Christian,
Laue Michael,
Möller Robert,
Naumann Dieter,
Deckert Volker,
Popp Jürgen
Publication year - 2009
Publication title -
journal of raman spectroscopy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.748
H-Index - 110
eISSN - 1097-4555
pISSN - 0377-0486
DOI - 10.1002/jrs.2123
Subject(s) - raman spectroscopy , tobacco mosaic virus , raman scattering , virus , identification (biology) , virology , nanotechnology , optics , materials science , chemistry , biology , physics , botany
The development of fast identification techniques of viruses is an ongoing important research topic. Conventional virus detection and identification is generally based on various different microbiological methods. However, these techniques are not suitable for the analysis of single virus particles. Therefore, our goal is to establish tip‐enhanced Raman scattering (TERS), providing vibrational spectroscopic information with a spatial resolution less than 50 nm, to characterize single viruses at a molecular level. Here we report, to the best of our knowledge for the first time, about TERS spectra of a tobacco mosaic virus, showing the great capability of this technique. However, the application of the TERS technique for a rapid and direct detection of different species of single viruses is under development, which is useful for a wide range of analytical fields. Copyright © 2008 John Wiley & Sons, Ltd.